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38 Therefore, it is essential to design further clinical studies addressing the clinical efficacy of the anticancer effect of vitamin C to set up appropriate evidence for the clinical efficacy of vitamin C in practical guidelines
The construction of the mutant proteins was achieved by site-directed PCR mutagenesis using mutagenic primers (Table S1)
18 Additionally, oral administration leads to hepatic first-pass metabolism and intestinal enzymatic degradation prior to the arrival of the drug in the brain
Molecular Chaperones in Protein Folding and Proteostasis
