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doi: 10.1093/ageing/afg109

Starting low and adjusting based on results and tolerance is the recommended approach

Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

While B12 is essential for various bodily functions, elevated levels may warrant further investigation