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Elevated superoxide levels can damage iron-sulfur cluster proteins, and elevated H 2 O 2 can lead to the formation of hydroxyl radicals, which in the presence of polyunsaturated fatty acids can generate lipid hydroperoxides that induce ferroptosis, a type of cell death

Besides MLH1 , which is often mutated or downregulated in the context of CDDP resistance, 126, 127, 128, 129 these genes include Rho GDP dissociation inhibitor beta ( ARHGDIB ), armadillo repeat containing, X-linked 2 ( ARMCX2 ), collagen, type I, 1 ( COL1A1 ), filamin A ( FLNA ) filamin C ( FLNC ), mesoderm-specific transcript ( MEST ), neurotensin ( NTS ) and proteasome (prosome, macropain) subunit, type, 9 ( PSMB9 ), pointing to the existence of hitherto unexplored mechanisms whereby malignant cells can lose their sensitivity to CDDP

437,438,439 Aminosalicylic acid preparations Aminosalicylic acids are a group of nonsteroidal anti-inflammatory drugs that have analgesic and anti-inflammatory effects and can reduce inflammation and pain by suppressing the synthesis of prostaglandins

It was found that the initial glutathione could be partially predicted (adjusted R 2 = 0.25, p = 0.003) based primarily on excretion of cadmium, lead, tin, thallium, and arsenic