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Am J Med Genet A 126A:267271 [DOI] [PubMed] [Google Scholar] de Rijke CE, Jackson PJ, Garner KM, van Rozen RJ, Douglas NR, Kas MJ, Millhauser GL, Adan RA 2005 Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness

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In the context of rare metabolic disorders, non-genetic factors- including dietary interventions- may represent disease modifiers that influence the variable phenotypic outcomes of inherited pathogenic variants

For instance, those with high physical activity may benefit from slightly higher doses, whereas people with pre-existing medical conditions may need to lower the dosage accordingly