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For how bioregulators fit into the hallmarks of aging framework, see The Hallmarks of Aging: Which Peptides Target Which

doi: 10.1016/j.ijpharm.2015.04.031

Ferritinophagymediated ferroptosis facilitates methotrexateinduced hepatotoxicity by highmobility group box 1 (HMGB1)

Clinicians will adjust the dose of ICS based on the patients symptom severity, history of acute exacerbations, and other co-morbidities to ensure that treatment is both effective and safe (182)