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Conversely, the Diabetes Control and Complications Trial observed few improvements in cognitive performance in patients with T1DM (139), suggesting distinct mechanisms underlying cognitive decline in T1DM and T2DM
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Genotoxicity evaluation encompassed an Ames mutagenicity evaluation, a chromosomal aberration assay in Chinese hamster ovary (CHO) cells, and a bone micronucleus assay incorporated within a 4-week toxicology study in murine models
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