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ROS are chemically reactive oxygen-containing species, such as superoxide, peroxides, hydroxyl radical, singlet oxygen and alpha-oxygen, etc
This suppressive effect of hemin is reversible by DMF, which induces CBS expression in an NRF2-dependent and independent manner
Kamada, R
Currently there is a clinical trial using YIV906 in patients with hepatocellular cancer being treated with sorafenib [24]
