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inhibitory interventions, on the other hand, primarily impede the process by disrupting cytoskeletal architecture, interfering with intercellular connections, or reducing mitochondrial quality

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For example, enhancing CMA could provide a specific route for the degradation of toxic proteins in neurodegenerative diseases, while inhibiting aggrephagy in cancer could lead to the accumulation of protein aggregates and induce cell death

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This configuration markedly diminishes the probability of premature metal dissociation prior to arriving at the designated target (Petersen et al., 2024

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They are commonly referred to as phase II enzymes

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