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inhibitory interventions, on the other hand, primarily impede the process by disrupting cytoskeletal architecture, interfering with intercellular connections, or reducing mitochondrial quality

For example, enhancing CMA could provide a specific route for the degradation of toxic proteins in neurodegenerative diseases, while inhibiting aggrephagy in cancer could lead to the accumulation of protein aggregates and induce cell death

This configuration markedly diminishes the probability of premature metal dissociation prior to arriving at the designated target (Petersen et al., 2024

They are commonly referred to as phase II enzymes
