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The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

doi: 10.1016/j.neuron.2019.12.025, PMID: [DOI] [PubMed] [Google Scholar] Zheng J., Stevenson R

Risk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case-control study

Further research on the methods used to determine GSH levels in the living human brain as well as a better definition of standard procedures for analyzing GSH contents by MRS in the brain are warranted to obtain a more consistent picture on alterations in the GSH levels in the human brain in health and disease