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Consistent with this hypothesis, fasting induces both lipase genes and autophagy genes via activation of the HLH-30 transcription factor
2), suggesting a potential role for siRNAs and the involvement of Pol IV and Pol V in retrotransposon regulation
Although the initial approval for the United States would be with peginterferon- and ribavirin, daclatasvir in combination with sofosbuvir achieved SVR12 in 98% of 126 treatment-naive genotype 1 patients and 98% of 41 protease inhibitor failures (23)
