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The best candidate, (E)-1-(4-(2-(9-ethyl-9H-carbazol-3-yl)vinyl)phenyl)-3-(2-(pyrrolidin-1-yl)ethyl)thiourea), showed good inhibitory activities against AChE and BChE, and significant inhibition of self-mediated A1-42 aggregation

These constants allow quantification of the proton binding capacity of submolecular basic units when the protonation states of all other sites are defined in the molecule [79]
