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The increased entry of calcium ions (Ca2+) into mitochondria can lead to ROS generation and depolarization of the mitochondrial membrane, all occurring without ATP synthesis (Susin et al., 1998

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Ethics statement The animal study was reviewed and approved by the Committee of Laboratory Animal Experimentation at Southwest University

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These include gastrointestinal bleeding, kidney impairment or allergic reaction

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The results showed that polysaccharides extracted from Pleurotus ostreatus can scavenge DPPH and ABTS free radicals, absorb water and have an inhibitory effect on collagenase and elastase activity

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