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Effect of BER chitosomes and BER solution on dopamine and -synuclein in rat model of parkinsonism In earlier studies, rotenone decreased the level of dopamine and increased oxidative stress along with marked degeneration of dopaminergic neurons [94]

10.1007/s00018-020-03454-6 47 FardM.Akhavan-TavakoliM.KhanjaniS.ZareS.EdalatkhahH.ArastehS.et al (2018)

6.1 Glutathione metabolism: modern view of biosynthetic pathways, NADPH dependence, and relationship to thioredoxin The synthesis of glutathione (GSH) predominantly occurs through the ATP-dependent -glutamyl cycle, beginning with the action of glutamate-cysteine ligase (GCL), the key rate-limiting enzyme composed of two subunits: a catalytic component (GCLC) and a regulatory modifier (GCLM)