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Similar results were reported in Drosophila (11-16% extension) and other rodent strains Telomere studies: Multiple in vitro studies confirmed telomerase activation and measurable telomere elongation in human somatic cells

Senomorphics target these epigenetic regulators to reverse or slow down senescence.136 Some compounds reactivate silenced genes or suppress harmful gene expression, thus modifying the aging process at the molecular level.137 Maintenance of Mitochondrial and Metabolic Homeostasis: Mitochondrial dysfunction is a major driver of cellular senescence, leading to increased reactive oxygen species (ROS) production, metabolic decline, and energy deficits.138 Senomorphics enhance mitochondrial function by stimulating mitophagy (removal of damaged mitochondria), improving oxidative phosphorylation, and reducing oxidative stress, thereby promoting healthier cellular metabolism.66 Modulation of DNA Damage Response (DDR) and p53/p21 Pathways: Cellular senescence is often triggered by DNA damage, which activates the DNA damage response (DDR) and key regulatory pathways such as p53/p21 and p16INK4a/Rb.55 While these pathways prevent damaged cells from proliferating, they also promote inflammation and tissue dysfunction if senescent cells persist

Lie DC, Colamarino SA, Song HJ, Desire L, Mira H, Consiglio A, et al

The active region of TB-500 (the LKKTETQ sequence) binds G-actin monomers, preventing their polymerization into filamentous F-actin