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For example, damage-associated molecular patterns (DAMPs) or KRAS G12D proteins released from ferroptotic cells can be packaged into exosomes and internalized by macrophages, transforming them into the M2-like phenotype and leading to an immunosuppressive environment [118]
Another possibility is with the inclusion of a large number of candidate genes, there is always a risk of false positive associations
Understanding these distinctions helps explain why researchers choose one over the other
