glutathione causes kidney failure is the body's most powerful antioxidant and plays a primary role in the protection of all cells from daily metabolic stress, oxidative stress and toxic chemicals. Deficiency of glutathione contributes to Frontiers | Diabetic kidney disease:

The physiological functions of iron include participating in the mitochondrial respiratory chain and hemoglobin synthesis

Sorafenib induces mitochondrial dysfunction and exhibits synergistic effect with cysteine depletion by promoting HCC cells ferroptosis

308 In vitro studies have shown that the addition of S1P to microglia subjected to oxygen-glucose deprivation/reperfusion exacerbates hypoxia-induced neuronal apoptosis

This was, however, not the case for the E2 metabolites: the abundance of 2- and 4-MeOE2 was still the lowest of all the metabolites and similar to that found in the control group (Supplementary Table S2)