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Some authors suggest that impairments within the endogenous opioid system, such as those proposed here, may, over time, lead to the hyperactivation of pain pathways, and, therefore, transform normal stimuli into painful or heightened responses toward typical pain stimuli (allodynia and hyperalgesia, respectively) [137]

Dieting and weight loss regimes, notably those which are rapid or extreme, can also result in nutritional deficits, including B vitamins

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