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Therefore, before initiation of TRT, it is important to consider the possible presence of risk factors of persistent HH and the time since normoprolactinemia was achieved, usually starting after 3-6 months since then (12)
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Therefore, IGF-1 prevents the loss of dopaminergic neurons and improves motor function in PD model by upregulating the PI3K/AKT/GSK3/MAPK/ERK pathway
