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Circulation 131: 13131323 Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y (2003) Defective brain development in mice lacking the Hif1alpha gene in neural cells

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In a clinical study of obese men treated with liraglutide (a type of GLP-1 RA), researchers found a significant increase in serum testosterone levels, beyond what would be expected from weight loss alone. Sperm Quality Researchers have also looked at how GLP-1 RAs affect sperm metabolism the processes by which sperm generate energy, move, and function properly