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We have evidence that it is effective, although it has only been studied in this area of the body

TMZ caused DNA damage and amplified the Mn 2+ induced cGAS-STING pathway, creating a substantial immunological synergistic effect with TMZ-induced ICD, presenting a promising strategy for treating metastatic melanoma

Activation of those genes, in turn, has been shown to extend the lifespan in a wide variety of organisms and to reduce the incidence of age-related diseases, such as diabetes, cancer, immune deficiencies, and cardiovascular disorders (Bordone and Guarente 2005)
George Clooney: A Biography
