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Mitochondria are major sources of free radicals, and in addition to being commonly used to treat disoriented circadian clocks due to jet lag and other disturbances (i.e., sleep inefficiency) 18 , melatonin has been widely used as an antioxidative therapy 19 and its use dates back to 1993 (refs

Additionally, it may improve immune response and promote healthy blood vessel growth, supporting overall skin and tissue health

Shi, Z., Song, R., Zhang, L., Jiang, H., Jiao, L., Yuan, S., Chen, L., Meng, D

They can occur from traumatic injury such as a twisting of the leg when the foot is planted, or from degenerative changes
