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Notably, a statistically significant reduction in CCL2 mRNA was exclusively observed in the control group (from 2 0.2 to 2 0.1 , p = 0.01), suggesting distinct gene-specific responses to the combined effects of supplementation and physical training ( Table 2 Effects of vitamin C supplementation combined with exercise on metabolic profiles, immune-related gene expression, muscle, vascular, and hepatic outcomes in elderly subjects

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