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Collectively, these findings suggest that modulating key factors within the HIF-1 signaling pathway, both upstream and downstream, can effectively optimize effector cell metabolism, diminish the proliferation and overactivation of abnormal, self-reactive cells, and subsequently ameliorate tissue inflammation in SLE patients, particularly those with LN

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Furthermore, they showed that Win-1001X extract mainly targets autophagy and antioxidant mechanisms and reduced neuroinflammation [125]

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