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176 When compared to insulin, insulin-like growth factor 1 (IGF1) showed relative lower binding affinity to insulin receptors

More Powerful Glycemic Control Both tirzepatide and retatrutide significantly improve blood sugar control

Wang et al., 2021a

The acetyl group protects the thiol moiety from premature oxidation during gastrointestinal transit, though plasma half-life remains short (2-3 hours) due to rapid hepatic metabolism
