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Very low or high blood levels of homocysteine can indicate a B12, folate, and/or B6 deficiency (21)

How to supplement when B12 tests are high Be sure you remove all sources of synthetic cyanocobalamin from your diet (supplements & fortified foods) Consider supplementing with iodine, selenium, and molybdenum which helps activate B2 (a B12 transport helper) Consider supplementing with an active B2 form (Riboflavin-5-Phosphate) - a B12 transport cofactor Consider taking intrinsic factor which helps the gut better absorb B12 Consider pulsing 4.5 mg of lithium orotate (2-3x per week) - helps the B12 transport Only supplement with bioidentical active B12 forms - hydroxocobalamin, methylcobalamin, adenosylcobalamin I know my specific COMT & VDR Taq gene details

Inhibition of neuronal Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices

Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat