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They are implicated in cell-to-cell interactions, cellextracellular matrix interactions, receptor crosslinking or lattice formation, intracellular signaling, and posttranscriptional splicing (90)

Larazotide appears to help modulate intestinal permeability by impacting barrier function

J Neuroimmunol 166:144157

Important caveats Large-scale, long-term human outcome data are limited
