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10.1016/j.heliyon.2022.e10236 215 ZhangX.YangK.ChenL.LiaoX.DengL.ChenS.et al (2019)
Loss of NAD + levels results in impairment of mitochondria function, which leads to failure of essential metabolic processes (Reid et al., 2018)
Global PGC-1 knockout mice display unexpected metabolic phenotypes - reduced adiposity and increased physical activity despite compromised mitochondrial capacity (123)
Another promising method is the supercritical carbon dioxide (CO 2 )-based decellularization, which may better preserve the native composition of the ECM (Matthews et al., 2018)
