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Presumably, the dry skin results from normalization of differentiation and proliferation of the keratinocytes and loosening of their adhesion to one another, thereby resulting in flaky skin.[25] One can also speculate that a topical retinoid would also bind to the sebocytes retinoid receptors, resulting in decreased sebum production, but evidence has yet to exclusively illustrate that topical retinoids are sebosuppressive.[26] Both tazarotene and tretinoin have been reported to reduce facial pore size

Furthermore, a more recent study has shown decreased TPP levels in plasma from ASD children compared to healthy controls (147), suggesting either lower consumption or an impaired absorption from the gastrointestinal tract, providing a link between thiamine metabolism and the gut microbiome, which has been considered in the context of ASD (148)

10.1111/j.1471-4159.2005.03379.x [DOI] [PubMed] [Google Scholar] Buccellato F