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This Primer describes the current knowledge surrounding B12 deficiency, and highlights improvements in diagnostic methods as well as shifting concepts about the prevalence, causes and manifestations of B12 deficiency

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Zivanovic-Posilovic G., Balenovic D., Barisic I., Strinic D., Stambolija V., Udovicic M., Uzun S., Drmic D., Vlainic J., Bencic M.L., et al

I do admit this could just be the types of clients I see in clinic, and maybe none of the clients Ive worked with react to B12 or biotin supplements (remember that study listed 1 person reacting, out of 10 people)

Hydroxocobalamin is also an effective scavenger of nitrogen oxides (nitrogen radicals) responsible for the so-called nitrosative stress involved in the development of many diseases