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Description
Lean tissue accounted for approximately 39% of total weight lost (Wilding et al., NEJM , 2021)

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In addition, mitochondrial dysfunction can lead to the release of endonuclease G that causes nuclear DNA fragmentation which contributes to cell death 27,29 , but has also been associated to senescence 31,32

As expected, increased expression of NLRP3 in the endometrial tissue has been implicated in the pathogenesis of higher miscarriage rates in PCOS patients (59)
