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This was in contrast to LDL uptake by the LDLR, which is markedly downregulated when cellular cholesterol levels rise (Figure 2)

Photoaging and tobacco smoke-induced aging are similar and include the adverse effects of oxidative stress (141)

Long-term inflammation and H 2 O 2 /O/OH/ 1 O accumulation may damage the DNA of ESCs, increasing the risk of skin cancer [299]

However, this may change
