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LKB1, a tumor suppressor, is a major mammalian AMPK kinase in the liver that activates AMPK by phosphorylating the Thr172 residues of AMPK subunits
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A Low FODMAP diet is recommended
174 In contrast, negative regulators of the NLRP3 inflammasome, such as the E3 ligase A20/TNF--induced protein 3 and TGF--activated kinase 1 (TAK1), prevent its excessive activation and suppress inflammation
