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Journal of Clinical Pharmacy and Therapeutics, 26 (5), 363-367

[DOI] [PubMed] [Google Scholar] 5.Bora T, Nuraln F, enocak N, Aydn H
Previous studies have reported an increase in the levels of nerve growth factor [13], lactate [14], and interleukin (IL)-1 at the incision site [15]
The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study
