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3.2 Induction of apoptosis Among the six major anthocyanidins, only those with an ortho-dihydroxyphenyl structure on the B ring demonstrate pro-apoptotic activity

In HFD-induced obese insulin-resistant rats subjected to cardiac ischemiareperfusion injury, dapagliflozin, an SGLT2 inhibitor, exhibited superior cardioprotective efficacy compared with vildagliptin, a DPP-4 inhibitor, as evidenced by suppression of mitochondrial Drp1 expression, reduced infarct size, and improved left ventricular function [199]

showed that IC/BPS subjects had increased fungal members of the urobiome during symptoms flares [47]

During acidosis, there is a shift from the metabolization of other substrates of gluconeogenesis (e.g., lactate) towards glutamine [93]