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Given the possibility that cimetidine may benefit a subset of patients without significant AEs in the context of a small total sample exposed to the drug (n=40, including the RCT), the lack of long-term follow-up data on sufficient numbers of patients, and its potential to interact with other drugs, oral cimetidine was designated as an Option

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Complementary findings in dietary obesity models have also been reported, where AgRP levels were elevated under hyperphagic conditions and reduced with food restriction, while -MSH and POMC concentrations remained unchanged [60]