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In clinical trials on insulin resistance and type 2 diabetes, phenylbutyrate could significantly improve peripheral insulin sensitivity (Rd:13.2 1.8 vs
Brookes M, Revell WJ
Adult-onset type 1 diabetes is more heterogeneous than childhood-onset type 1 diabetes
10 This finding raises the question of whether the activation of p70S6K1 by OSI-906 is through IGF-1R inhibition or it is a non-specific effect of OSI-906
