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Reference: Khavinson VK, Vityuk OV

Furthermore, another study [124] with 82 cigarette smokers, oral 2-phenethyl isothiocyanate (PEITC), a cruciferous-based compound from watercress, was able to lead to increased detoxification of the volatile carcinogens, benzene and acrolein with an even stronger effect for those with the null genotype of both GSTM1 and GSTT1

Applying this model to approved and withdrawn medicines, we found that aldehyde metabolites produced from N-dealkylation may explain the hepatotoxicity of several drugs: indinavir, piperacillin, verapamil, and ziprasidone