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Considering the pro-apoptotic potential of curcumin and vitamin D3 in cancer cells, studying their individual and combined effects could be of benefit in the treatment of various malignancies (Talib et al., 2022)

For this reason, there are no specific HIF-1 inhibitors currently and developing specific HIF-1 inhibitors in hypoxic tumors represent a challenge

Methods In the interest of space, extensive details for this section are provided in the Online Supplementary Materials

The remaining authors declare no conflict of interest related to this study
