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Here, we synthesize these findings into a cohesive model of a bidirectional vicious cycle that amplifies neuropathology and drives the progression of depressive disorders (Figure 3)

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and Long, J.A., "Control of Arabidopsis apical-basal embryo polarity by two antagonistic transcription factor families", Nature 464 (7287): 423-426 (2010)

They also have advantages such as high biocompatibility and good slow-release performance
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