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Avoid compensating by doubling subsequent doses, as this increases side effect risk without recovering the lost metabolic advantage

Similarly, data from human studies that assessed the contribution of folate deficiency or folate supplementation on cancer risk or progression is inconsistent and varies significantly based on factors such as folate dose, mode of intake (dietary versus supplementary), stage of development during exposure (prenatal versus postnatal), and the pathological status (normal versus neoplastic) of tissues [121,122,123,124]

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