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Importantly, we find that the ISR pathway is required for efficient epithelial cell differentiation and lytic EBV reactivation in NOKs and show that expression of CHOP alone is sufficient to induce lytic EBV reactivation and differentiation

It is frequently explored in research related to adipose tissue breakdown, reduced lipogenesis, metabolic regulation, and mechanisms affecting energy utilization without influencing IGF-1 activity

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These findings were confirmed in vivo, in nude mice bearing U937 tumours coinjected with recombinant hGH and the NF-B -inducing anticancer drug daunorubicin, to avoid the in vivo toxicity of TNF-