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The action of the hydroxyl free radical on cardiolipin releases 4-hydroxynonenal (4-HNE) and on other mitochondrial lipids and mtDNA releases malondialdehyde (MDA), acrolein, and crotonaldehyde
Other populations at risk include people who had gastrointestinal surgery (including weight loss surgery) and diseases that affect the gut, such as Crohn's disease or celiac disease
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