ergothioneine and glutathione sources Distribution accumulation of dietary and its metabolites in mouse tissues Ergothioneine vs Glutathione: What's Better

One week on a plant-based diet can significantly drop blood levels of homocysteine, a toxin

(For reviews, see Anders, 2004, Anders, 2008, Cooper, 1998, Cooper and Pinto, 2008, Cooper et al., 2011, Dekant, 2003, Dekant et al., 1994.) The reactive fragments generated from haloalkene cysteine S -conjugates by the action of cysteine S -conjugate -lyases are especially cytotoxic in experimental animals to the proximal renal tubules, in particular to the S 3 ( pars recta ) region and, to a lesser extent, the S 1 and S 2 ( pars convoluta ) region (e.g., Jones et al., 1988) and to isolated human proximal tubules (Chen et al., 1990)

While glutathione is generally considered safe when taken in appropriate doses, excessive supplementation can result in side effects like gastrointestinal discomfort, nausea, and allergic reactions

23 , 350354, doi: 10.1165/ajrcmb.23.3.4076 (2000)