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214,215 In clinical trials in subjects with herpes lesions on the lips, a 0.5% topical propolis extract solution was more effective than topical use of the antiviral drug acyclovir for shortening time to healing and reducing symptoms such as pain, burning, itching, tension, and swelling

A dose of 10 mg/kg significantly reduced spontaneous pain without signs of dependency or sedation

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Most vitamin Bs are readily available in foods, but vitamin B12 is not available from plants