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Much of the mechanistic insight stems from animal models or in vitro systems, which may not accurately replicate the physiological complexity of human perimenopause

However, lasers should be used with caution in melasma treatment, especially in darker skin tones, because it can often worsen melasma and hyperpigmentation

Hallman et al

Neuromodulation and the gut-brain axis: therapeutic mechanisms and implications for gastrointestinal and neurological disorders
