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When activated, mast cells release a cascade of inflammatory mediators, including: This can disrupt the BBB, promote leukocyte infiltration, and create a pro-inflammatory CNS microenvironment

Short term effects include dehydration and intoxication, while more long-term effects can include changes in the metabolism of the liver and brain

Additionally, MK-677 enhances sleep architecture by extending slow-wave sleep phases, which represents the deepest stage of rest

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