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Vitamin C sensitizes pancreatic cancer cells to erastin-induced ferroptosis by activating the AMPK/Nrf2/HMOX1 pathway

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This pathological phenomenon is frequently ascribed to the interrelated influences of various factors, such as severe environmental conditions, distinct morphological variations among individuals, and possible clinical risk factors (Leon and Bouchama, 2015)

Excess Cu ions induce cuproptosis by promoting the insoluble oligomerization of lipoylated proteins in TCA cycle, suppressing Fe-S cluster protein, causing proteotoxic stress and elevating HSP70, ROS (Figure 3) (Tsvetkov et al., 2022)