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Description
In clinical trials with tirzepatide injection for type 2 diabetes mellitus (T2DM), 106 (4.1%) of patients receiving tirzepatide tested positive for anti- tirzepatide antibodies and had hypersensitivity reactions

Development of AngIV-based analogs Given the above research findings regarding Nle-AngIVs ability to facilitate synaptogenesis and memory consolidation via stimulating the HGF/c-Met system in animal models of AD AngIVbased pharmaceuticals have been proposed as therapeutic agents to treat AD (reviewed in [45,92])

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These aliases do initially deliver messages, but engagement is typically low
