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Moreover, free glutarate was not detected in GCDH-deficient cells, indicating that HeLa cells can metabolically adapt to avoid excess glutaryl-CoA
K.TiwariA.SinghR
Mitophagy receptor FUNDC1 is regulated by PGC-1alpha/NRF1 to fine tune mitochondrial homeostasis
The resulting lactate-rich, acidic TME further reinforces tumor progression via histone lactylation, an epigenetic modification linking metabolic byproducts to transcriptional reprogramming
