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[email protected] Received: Accepted: How to cite this article: Vijay V, Ahmed M, Singh Y

Under the guidance of the spleen-kidney correlation theory, exploration into the modern mechanisms underlying Yishen Huashi granules in treating RF has revealed that it can increase the intestinal flora content, such as Lactobacillus and Lactobacillus murinus , as well as serum metabolites such as phosphatidylethanolamine through the "gutkidney axis", thereby regulating the expression of mRNAs such as Adcy3 in the kidney and adjusting pathways related to glucose and lipid metabolism to improve DN [177]

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Additionally, GLP1 has been associated with a reduction in the risk of cardiovascular events in people with obesity, suggesting potential benefits beyond weight loss alone